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A 2018 study published in Biochemical Pharmacology showed that inhibiting NNMT with 5-Amino-1MQ led to a reduction in fat mass in mice on high-fat diets

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[1] 5-Amino-1MQ is the short name commonly used for 5-amino-1-methylquinolinium iodide, a quinolinium small molecule studied as an inhibitor of nicotinamide N-methyltransferase (NNMT)