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Structural studies of retatrutide bound to GLP-1R, GIPR, and GCGR have been deposited in the Protein Data Bank, supporting docking, mutagenesis, and structure-activity work in computational pharmacology

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However, it remains unlicensed in the UK not approved by the MHRA or EMA meaning robust, sex-specific safety data are still limited

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At higher levels, mobility and decision-making abilities are severely compromised