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Summary: Semaglutide reduces the need for loop diuretics and improves symptoms, physical limitations, and body weight in patients with heart failure with preserved ejection fraction (HFpEF), regardless of diuretic use, according to research presented at Heart Failure 2024

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In the most directly relevant comparator with semaglutide, MASH resolution was achieved in 62.9% of patients on the drug while fibrosis improvement reached only 36.8%, leaving substantially less overlap than the headline numbers might imply [16]

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